Product Name: Pluracare E 400
Chemical Family: Polyethylene glycol, nonionic surfactant
Synonyms: PEG 400, Poly(oxy-1,2-ethanediyl), Pluracare E400
Recommended Use: Personal care formulations, industrial applications, cosmetics, pharmaceuticals, food additives
Manufacturer: BASF SE
Emergency Telephone Number: Refer to local emergency contact
Product Code: Various supplier references
Hazard Classification: Not classified as hazardous under GHS
Physical Hazards: May form combustible mixtures at elevated temperatures, low volatility
Health Hazards: May cause mild eye and skin irritation on prolonged contact
Environmental Hazards: Low toxicity to aquatic life, fully miscible with water
Pictograms: None required
Signal Word: None
Hazard Statements: May cause slight irritation to skin and eyes
Precautionary Statements: Avoid eye and prolonged skin contact, ensure ventilation
Chemical Name: Polyethylene Glycol
CAS Number: 25322-68-3
Concentration: ≥ 99%
Impurities: Trace levels of related homologues
Additives: None present
Eye Contact: Flush with copious water for several minutes, remove contact lenses if worn, seek medical attention for persistent discomfort
Skin Contact: Remove contaminated clothing, wash skin thoroughly with soap and water
Inhalation: Move person to fresh air, seek medical attention if symptoms persist
Ingestion: Rinse mouth, do not induce vomiting, get medical help if large quantities are consumed or symptoms develop
Most Important Symptoms: Eye or skin irritation
Notes to Physician: Treat symptomatically, no specific antidote
Suitable Extinguishing Media: Water spray, dry powder, foam, carbon dioxide
Unsuitable Media: High-pressure water jets
Specific Hazards: Combustion may produce carbon monoxide, carbon dioxide, and other harmful vapors
Protective Equipment: Wear self-contained breathing apparatus and protective clothing
Fire Fighting Instructions: Contain runoff, cool containers exposed to heat
Hazardous Combustion Products: Carbon oxides, low molecular weight aldehydes
Special Procedures: Avoid breathing fumes, prevent entry into water sources
Personal Precautions: Wear safety glasses, gloves, and protective clothing to avoid skin and eye contact
Environmental Precautions: Prevent entry into drains, water courses, or soil
Clean-up Methods: Absorb material with inert absorbents such as sand or earth, transfer to containers for disposal
Spill Area Ventilation: Increase ventilation to dissipate vapors
Decontamination: Wash spill site after material pick-up
Disposal of Contaminated Material: Collect in labeled drums for safe disposal
Precautions for Handling: Avoid prolonged or repeated skin contact, wear protective gear
Hygiene Measures: Wash hands thoroughly before eating, drinking, or smoking
Technical Measures: Use only with adequate ventilation
Storage Conditions: Store in tightly closed original containers, keep in a cool, dry, well-ventilated area
Incompatible Materials: Strong oxidizing agents, acids, alkalis
Storage Temperature: Protect from freezing and excessive heat
Safe Packaging Materials: Keep in polyethylene, stainless steel, or glass containers
Occupational Exposure Limit: No established limits for polyethylene glycol
Engineering Controls: Use local exhaust or general room ventilation
Personal Protective Equipment:
Gloves – chemical resistant (nitrile, neoprene)
Eye Protection – safety glasses or goggles
Skin Protection – protective clothing
Respiratory Protection – not typically required, use if ventilation is inadequate
Work Practices: Avoid contact with skin, eyes, and clothing, do not eat, drink, or smoke while handling
Environmental Exposure Controls: Minimize release to the environment
Appearance: Clear, colorless, viscous liquid
Odor: Slight, characteristic
Odor Threshold: Not applicable
pH (as supplied): Neutral (5.0-7.0)
Melting Point/Freezing Point: ~4°C
Boiling Point: >250°C
Flash Point: ~221°C (closed cup)
Evaporation Rate: Negligible
Flammability: May burn at elevated temperatures
Vapor Pressure: <0.01 hPa at 20°C
Vapor Density: Not available
Specific Gravity: 1.12 – 1.15 at 20°C
Solubility: Fully miscible with water
Partition Coefficient (n-octanol/water): Not available
Auto-ignition Temperature: >370°C
Decomposition Temperature: Not available
Viscosity: 75-95 mPa·s at 20°C
Chemical Stability: Stable under normal storage and handling
Conditions to Avoid: Excessive heat, open flame, sources of ignition
Incompatible Materials: Strong oxidizing agents, concentrated acids, alkalis
Possibility of Hazardous Reactions: None under normal use
Decomposition Products: Carbon dioxide, carbon monoxide, aldehydes at high temperatures
Polymerization: Will not occur
Acute Toxicity (Oral): LD50 > 15,000 mg/kg (rat)
Acute Toxicity (Dermal): LD50 > 20,000 mg/kg (rabbit)
Inhalation: Low volatility reduces risk, not considered a hazard
Skin Irritation: Possible mild irritation with repeated exposure
Eye Irritation: May cause mild, transient irritation
Chronic Effects: Prolonged contact can lead to defatting and dryness of skin
Carcinogenicity: Not listed as carcinogenic by IARC, NTP, ACGIH
Mutagenicity: No evidence of mutagenic activity
Reproductive Toxicity: No evidence from available data
Other Health Effects: No sensitization reported
Ecotoxicity: Not expected to harm aquatic organisms at predicted exposure concentrations
Fish Toxicity (LC50): >5000 mg/L (96h, Leuciscus idus)
Daphnia Toxicity (EC50): >10,000 mg/L
Algae Toxicity (IC50): >1,000 mg/L
Persistence and Degradability: Readily biodegradable under aerobic conditions
Bioaccumulation Potential: Low potential, low log Kow
Mobility in Soil: High mobility; not expected to adsorb significantly to soil
Other Adverse Effects: None known
Waste Treatment Methods: Dispose via licensed chemical waste contractor
Disposal of Product: Incineration in compliance with local regulations
Disposal of Contaminated Packaging: Clean containers before local recycling or disposal
Environmental Precautions: Avoid release to watercourses or soil
Sewage Disposal: Avoid disposal through wastewater systems
Regulatory References: Dispose in line with regional, national, and local laws
UN Number: Not regulated
UN Proper Shipping Name: Not regulated
Transport Hazard Class: Not regulated
Packing Group: Not regulated
Environmental Hazards: Not considered hazardous for transport
Special Precautions: Prevent leaks and spillage during transit
Transport Labels: None required
Transport in Bulk (IMDG, IATA, ADR/RID): Not regulated; check local requirements
Labeling Requirements: Not classified under GHS or EU Classification, Labeling and Packaging (CLP) regulation
Inventory Listings: Registered under REACH, listed on TSCA, DSL, AICS, ENCS, EINECS
SARA Title III Sections 302/304/311/312/313: Not subject to reporting requirements
California Proposition 65: Not listed
OSHA Status: Not hazardous
CERCLA Reportable Quantity: Not applicable
International Regulations: Compliant with relevant directives in major global markets
