Product Name: Hexadecyl Primary Amine
Synonyms: Cetylamine, 1-Hexadecylamine, Palmitylamine
Chemical Formula: C16H35N
CAS Number: 143-27-1
Recommended Use: Surfactant, flotation agent, chemical intermediate
Supplier: Manufacturer or distributor contact information, emergency telephone numbers
Emergency Contact: National Poison Control Center or local emergency services
Classification: Acute toxicity, Skin corrosion/irritation, Serious eye damage/eye irritation, Hazardous to aquatic environment
Signal Word: Danger
Hazard Statements: Causes severe skin burns and eye damage; Harmful if swallowed; Causes serious eye irritation; Toxic to aquatic life with long-lasting effects
Pictograms: Corrosive, exclamation mark, environment
Precautionary Statements: Avoid breathing dust or vapors; Wear protective gloves, eye protection, face protection; Wash hands thoroughly after handling; Avoid release to the environment
Chemical Name: Hexadecylamine
Concentration: >95% by weight
Impurities: May contain trace amounts of related higher or lower chain amines or other residual chemicals from manufacturing process
Inhalation: Move exposed person to fresh air. Seek immediate medical attention if symptoms such as cough, shortness of breath, chest tightness, or dizziness appear.
Skin Contact: Remove contaminated clothing and rinse skin with plenty of water. Continue rinsing for at least 15 minutes. Seek medical attention for persistent irritation or burns.
Eye Contact: Rinse cautiously with water for several minutes, holding eyelids open. Remove contact lenses if present and continue rinsing. Immediate medical attention required.
Ingestion: Rinse mouth thoroughly with water. Do not induce vomiting. Seek medical attention immediately. Never give anything by mouth to an unconscious person.
Immediate Medical Attention: Required for ingestion, inhalation, or eye contact.
Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, alcohol-resistant foam, or water spray
Unsuitable Extinguishing Media: Direct water jet can spread burning liquid
Specific Hazards: May emit toxic fumes of nitrogen oxides, ammonia, and hydrocarbons under fire conditions
Protective Equipment: Wear self-contained breathing apparatus and full protective clothing
Firefight Approach: Evacuate area, use water spray to cool exposed containers, avoid breathing fumes
Personal Precautions: Wear appropriate protective clothing, gloves, and safety goggles. Ventilate area. Avoid inhalation, skin or eye contact.
Environmental Precautions: Prevent further leakage or spillage if safe to do so. Avoid discharge into drains, waterways, or soil.
Spill Cleanup Methods: Contain spilled material using inert absorbent such as sand or earth. Sweep up and place in a suitable container for disposal. Ventilate area and wash contaminated surfaces with plenty of water.
Special Precautions: Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment if necessary.
Handling: Avoid contact with skin, eyes, and clothing. Do not breathe dust, vapors, or spray. Wash thoroughly after handling. Use only with adequate ventilation.
Storage: Store in tightly closed containers. Keep in a cool, dry, well-ventilated area away from strong oxidizing agents, acids, and sources of ignition. Store away from direct sunlight and incompatible materials. Label containers clearly.
Special Requirements: Store in original packaging. Secondary containment recommended to prevent environmental release.
Engineering Controls: Use local exhaust ventilation or general dilution ventilation to control airborne concentrations.
Exposure Limits: No established occupational exposure limits for hexadecylamine. Observe good industrial hygiene practices.
Personal Protective Equipment:
Respiratory Protection: NIOSH-approved air-purifying respirator in dusty environments or if exposure limits are exceeded.
Hand Protection: Chemical-resistant gloves made of nitrile, neoprene, or PVC.
Eye Protection: Safety goggles or full-face shield.
Skin Protection: Protective clothing to prevent skin contact.
Hygiene Measures: Provide eyewash stations and safety showers in working area.
Appearance: White to yellowish waxy solid or flakes
Odor: Fishy, amine-like odor
Melting Point: 46–51°C (115–124°F)
Boiling Point: 322°C (612°F) at 760 mmHg
Flash Point: Greater than 130°C (266°F)
Solubility: Insoluble in cold water, soluble in alcohol, ether, and hot water
Vapor Pressure: Low, not significant at room temperature
Density: 0.8–0.85 g/cm³ at 20°C
pH: Alkaline in solution
Partition Coefficient (n-octanol/water): High, expected to bioaccumulate
Decomposition Temperature: Above 250°C with release of toxic fumes
Chemical Stability: Stable under recommended storage conditions
Reactivity: Reacts with strong oxidizers, acids, acid chlorides
Hazardous Decomposition Products: Ammonia, nitrogen oxides, and irritating fumes under fire or severe thermal decomposition
Hazardous Polymerization: Will not occur
Conditions to Avoid: Heat, flame, ignition sources, direct sunlight, incompatible chemicals
Acute Toxicity: Oral LD50 (rat): 980 mg/kg; causes burns to mouth, throat, and stomach.
Inhalation: Can cause respiratory tract irritation, coughing, shortness of breath. High concentrations can cause lung injury.
Skin Corrosion/Irritation: Causes severe skin burns; may cause allergic reaction in sensitized individuals.
Eye Damage/Irritation: Causes severe eye damage with possible corneal injury; may result in permanent damage.
Chronic Effects: Prolonged or repeated contact may result in dermatitis and skin sensitization.
Carcinogenicity: Not listed as carcinogenic by NTP, IARC, OSHA.
Mutagenicity: Not known to be mutagenic.
Reproductive Toxicity: No data available regarding reproductive effects.
Aquatic Toxicity: Highly toxic to aquatic organisms; long-term adverse effects in aquatic environments.
Persistence and Degradability: Readily biodegradable in water; may bioaccumulate due to high partition coefficient.
Bioaccumulation: Potential for bioaccumulation in aquatic organisms.
Mobility in Soil: Low mobility, tends to adsorb to soils and sediments.
Other Adverse Effects: Discharge into the environment may cause harm to aquatic ecosystems and threaten biodiversity.
Disposal Methods: Dispose of by incineration by approved chemical waste disposal contractor. Do not discharge into waterways, sewers, or soil.
Waste Codes: Contact local authority for guidance. Hexadecylamine waste classified as hazardous.
Container Disposal: Triple rinse containers, offer for recycling or disposal at approved facility.
Special Precautions: Wear personal protective equipment during disposal. Prevent environmental release.
UN Number: 2735
UN Proper Shipping Name: Amines, liquid, corrosive, n.o.s. (Hexadecylamine)
Transport Hazard Class: 8 (Corrosive)
Packing Group: II
Environmental Hazards: Marine pollutant
Special Precautions for Transport: Avoid transport with food and animal feedstuffs. Secure containers against shifting. Ship in accordance with local and international regulations.
Emergency Response Guide Number: 153
OSHA: Hazardous substance under OSHA regulations
TSCA: Listed on US TSCA Inventory
REACH: Registered for use in the European Union; subject to restrictions on discharge
SARA Title III: Not a Section 302 extremely hazardous substance; Section 313 reporting for certain releases may apply
DSL/NDSL (Canada): Listed
WHMIS Classification: Class E—Corrosive Material
Other Regulatory Status: Subject to chemical-specific workplace exposure, environmental emission, and waste management regulation under local, state, national, and international frameworks.
