Product Name: 4-Dimethylaminopyridine
SYNONYMS: DMAP; 4-(Dimethylamino)pyridine
CAS Number: 1122-58-3
Recommended Use: Used in organic synthesis as an acylation catalyst, nucleophilic catalyst, and in peptide chemistry.
Manufacturer Information: Supplier details provided by distributor or packaging label.
Emergency Contact: Refer to local emergency numbers and Poison Control Centers.
GHS Classification: Acute toxicity (oral - Category 3), Skin irritation (Category 2), Eye irritation (Category 2A)
Signal Word: Danger
Hazard Statements: Toxic if swallowed. Causes skin irritation. Causes serious eye irritation.
Pictograms: Skull and crossbones, Exclamation mark
Routes of Exposure: Inhalation, skin contact, ingestion, eye contact.
Precautionary Statements: Avoid breathing dust. Wash hands after handling. Wear protective gloves, clothing, and eye/face protection.
Symptoms: Severe abdominal pain, nausea, vomiting, irritation of skin and eyes, respiratory distress if inhaled.
Chemical Identity: 4-Dimethylaminopyridine
Chemical Formula: C7H10N2
Molecular Weight: 122.17 g/mol
Purity: Typically >98%
Impurities: Commercial samples may contain trace byproducts depending on source.
Other Ingredients: None significant if supplied as solid technical grade DMAP.
Inhalation: Move individual to fresh air immediately. Seek medical advice. Provide oxygen if breathing is difficult.
Skin Contact: Remove contaminated clothing. Wash skin thoroughly with soap and water for at least 15 minutes. Monitor for irritation.
Eye Contact: Flush with plenty of water for at least 15 minutes, keeping eyelids open. Remove contact lenses if present. Obtain medical attention.
Ingestion: Rinse mouth with water. Do not induce vomiting. Seek medical help right away.
Suitable Extinguishing Media: Dry chemical, CO2, foam, or water spray.
Specific Hazards: Releases toxic and irritating fumes (nitrogen oxides, carbon oxides, amines) on burning.
Protective Equipment: Full chemical-resistant clothing and self-contained breathing apparatus.
Firefighting Instructions: Use water spray to cool containers. Avoid inhaling decomposition products.
Explosion Data: Non-flammable as bulk solid, but fine dust may pose explosion risk.
Personal Precautions: Use appropriate personal protective equipment, including gloves, goggles, and mask. Avoid contact with eyes and skin.
Environmental Precautions: Prevent from entering drains or waterways.
Cleanup Procedures: Sweep up and collect in suitable labeled containers. Use inert absorbent for spills. Ventilate area.
Disposal: Store collected waste securely for disposal in accordance with regulations.
Safe Handling: Minimize dust generation. Avoid all unnecessary exposure. Handle in well-ventilated areas using local exhaust.
Incompatible Materials: Strong acids, oxidizers, acid chlorides.
Storage Conditions: Keep sealed in a cool, dry place, away from direct sunlight and incompatible substances. Use airtight containers.
Special Requirements: Emergency eye-wash and safety shower accessible in work area.
Engineering Controls: Use fume hood and local extraction to reduce dust exposure.
Personal Protection: Chemical-resistant gloves (nitrile or neoprene), lab coat or chemical apron, splash-proof safety goggles.
Respiratory Protection: Use NIOSH-approved respirators for dust.
Hygiene: Do not eat, drink, or smoke while handling. Wash hands before breaks and after handling. Remove contaminated clothing promptly.
Physical State: Crystalline powder or solid
Appearance: White to light beige powder
Odor: Faint amine-like
pH: 8.5 (1% aqueous solution)
Melting Point: 110-114°C
Boiling Point: Decomposes before boiling
Flash Point: 166°C (closed cup)
Solubility: Soluble in water, methanol, ethanol, ethyl acetate, and dichloromethane
Vapor Pressure: Negligible at room temperature
Density: 1.1 g/cm3
Chemical Stability: Stable under recommended storage conditions.
Hazardous Reactions: Reacts with strong acids, acid chlorides, and oxidizing agents.
Decomposition Products: Nitrogen oxides, carbon oxides, various amines.
Polymerization: Does not polymerize under normal conditions.
Conditions to Avoid: High heat, humidity, incompatible chemicals.
Acute Toxicity: Oral LD50 (rat): ~188 mg/kg
Routes of Exposure: Inhalation, ingestion, skin, eye.
Effects of Exposure: Irritation of eyes and skin, nausea, vomiting, headache, dizziness, respiratory distress.
Sensitization: Prolonged or repeated contact may cause allergic skin reactions.
Carcinogenicity: Not classified by IARC or ACGIH as carcinogenic.
Other Effects: Prolonged exposure may affect liver and kidneys based on studies with structurally similar compounds.
Aquatic Toxicity: Harmful to aquatic organisms at moderate concentrations
Persistence and Degradability: Bioaccumulative potential low; not rapidly biodegradable
Bioaccumulation: Not expected to accumulate significantly in aquatic life
Mobility in Soil: Moderate; soluble in water and may migrate through soil
Additional Information: Avoid uncontrolled release to the environment.
Disposal Methods: Incinerate or dispose of as hazardous chemical waste in accordance with local and national regulations.
Contaminated Packaging: Rinse thoroughly before disposal or recycling. Treat as hazardous waste.
Additional Advice: Do not release to sewer systems. Use a licensed chemical waste disposal contractor where appropriate.
UN Number: 2811 (Toxic solid, organic, n.o.s.)
UN Proper Shipping Name: Toxic solid, organic, n.o.s. (contains 4-Dimethylaminopyridine)
Transport Hazard Class: 6.1
Packing Group: III
Environmental Hazards: Not classified as marine pollutant
Special Precautions: Follow all applicable national/international transport regulations. Ensure packaging is undamaged and clearly labeled.
OSHA Status: Classified as hazardous
SARA Title III: Listed, Section 313 (Toxic chemicals)
TSCA: Listed on US TSCA Inventory
EU Classification: T (Toxic); Xi (Irritant); Risk Phrases: R25, R36/37/38
WHMIS Classification: D1B (Toxic), D2B (Irritant)
Other: Subject to reporting and workplace safety requirements in many jurisdictions
